Science
Science: Life Extension
Recent advances in life extension research emphasize the convergence of genomics, regenerative medicine, and artificial intelligence. Genome editing tools such as CRISPR-Cas9 are being refined to correct pathogenic mutations linked to age‑related diseases, while senolytic drugs are entering late‑stage clinical trials to clear senescent cells that drive tissue dysfunction. Parallel efforts in stem‑cell biology aim to rejuvenate organ systems by replacing aged cells with induced pluripotent stem‑derived tissues, and biomaterials research is developing scaffolds that mimic youthful extracellular matrices. AI-driven phenotyping platforms now enable high‑throughput screening of anti‑aging compounds, accelerating the identification of candidates that modulate key pathways like mTOR, AMPK, and NAD+ metabolism. These multidisciplinary strategies collectively aim to extend healthy lifespan by targeting the underlying cellular mechanisms of aging rather than merely treating symptoms.